The shrine honors an unusually diverse pantheon of nine deities, from sun goddess Amaterasu to Emperor Ōjin, reflecting the spiritual needs of Hokkaido's diverse pioneer community.

上川神社には天照皇大御神、大己貴大神のほか、少彦名大神、豊受姫神、大物主神、建御名方神、応神天皇などが祀られています。